Dataset Information

Change in pulmonary diffusion capacity in a general population sample over 9 years.

ABSTRACT:

Rationale

Data on the change in diffusion capacity of the lung for carbon monoxide (DLCO) over time are limited. We aimed to examine change in DLCO (?DLCO) over a 9-year period and its predictors.

Methods

A Norwegian community sample comprising 1,152 subjects aged 18-73 years was examined in 1987 and 1988. Of the 1,109 subjects still alive, 830 (75%) were re-examined in 1996/97. DLCO was measured with the single breath-holding technique. Covariables recorded at baseline included sex, age, height, weight, smoking status, pack years, occupational exposure, educational level, and spirometry. Generalized estimating equations analyses were performed to examine relations between ?DLCO and the covariables.

Results

At baseline, mean [standard deviation (SD)] DLCO was 10.8 (2.4) and 7.8 (1.6) mmol·min(-1)·kPa(-1) in men and women, respectively. Mean (SD) ?DLCO was -0.24 (1.31) mmol·min(-1)·kPa(-1). ?DLCO was negatively related to baseline age, DLCO, current smoking, and pack years, and positively related to forced expiratory volume in 1 second (FEV1) and weight. Sex, occupational exposure, and educational level were not related to ?DLCO.

Conclusions

In a community sample, more rapid decline in DLCO during 9 years of observation time was related to higher age, baseline current smoking, more pack years, larger weight, and lower FEV1.

SUBMITTER: Storebo ML

PROVIDER: S-EPMC5013260 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Publications

Change in pulmonary diffusion capacity in a general population sample over 9 years.

Storebø Michael L ML Eagan Tomas M L TM Eide Geir E GE Gulsvik Amund A Thorsen Einar E Bakke Per S PS

European clinical respiratory journal 20160902

<h4>Rationale</h4>Data on the change in diffusion capacity of the lung for carbon monoxide (DLCO) over time are limited. We aimed to examine change in DLCO (ΔDLCO) over a 9-year period and its predictors.<h4>Methods</h4>A Norwegian community sample comprising 1,152 subjects aged 18-73 years was examined in 1987 and 1988. Of the 1,109 subjects still alive, 830 (75%) were re-examined in 1996/97. DLCO was measured with the single breath-holding technique. Covariables recorded at baseline included s ...[more]

PMID: 27600696

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Dataset Information

Change in pulmonary diffusion capacity in a general population sample over 9 years.

Rationale

Methods

Results

Conclusions

Publications

Change in pulmonary diffusion capacity in a general population sample over 9 years.

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