Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family.

ABSTRACT: Protein tyrosine phosphorylation, which plays a vital role in a variety of human cellular processes, is coordinated by protein tyrosine kinases and protein tyrosine phosphatases (PTPs). Genomic studies provide compelling evidence that PTPs are frequently mutated in various human cancers, suggesting that they have important roles in tumor suppression. However, the cellular functions and regulatory machineries of most PTPs are still largely unknown. To gain a comprehensive understanding of the protein-protein interaction network of the human PTP family, we performed a global proteomic study. Using a Minkowski distance-based unified scoring environment (MUSE) for the data analysis, we identified 940 high confidence candidate-interacting proteins that comprise the interaction landscape of the

SUBMITTER: Li X 

PROVIDER: S-EPMC5013315 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature