Wnt4 is a novel biomarker for the early detection of kidney tubular injury after ischemia/reperfusion injury.

ABSTRACT: Earlier intervention after acute kidney injury would promote better outcomes. Our previous study found that Wnt proteins are promptly upregulated after ischemic kidney injury. Thus, we assessed whether Wnt4 could be an early and sensitive biomarker of tubular injury. We subjected mice to bilateral ischemia/reperfusion injury (IRI). Kidney and urinary Wnt4 expression showed an early increase at 3 hours and increased further at 24 hours post-IRI and was closely correlated with histopathological alterations. Serum creatinine slightly increased at 6 hours, indicating that it was less sensitive than Wnt4 expression. These data were further confirmed by clinical study. Both kidney and urinary Wnt4 expression were significantly increased in patients diagnosed with biopsy-proven minimal change dis

SUBMITTER: Zhao SL 

PROVIDER: S-EPMC5013493 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature