Decarboxylative Annulation of α-Amino Acids with γ-Nitroaldehydes.

ABSTRACT: Indolizidine and quinolizidine derivatives are readily assembled from proline or pipecolic acid and γ-nitroaldehydes by means of a decarboxylative annulation process. These reactions are promoted by simple acetic acid and involve azomethine ylides as reactive intermediates. The method was applied to the synthesis of an epiquinamide analog.

SUBMITTER: Kang Y 

PROVIDER: S-EPMC5013532 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature