Cross-species identification of genomic drivers of squamous cell carcinoma development across preneoplastic intermediates.

ABSTRACT: Cutaneous squamous cell carcinoma (cuSCC) comprises 15-20% of all skin cancers, accounting for over 700,000 cases in USA annually. Most cuSCC arise in association with a distinct precancerous lesion, the actinic keratosis (AK). To identify potential targets for molecularly targeted chemoprevention, here we perform integrated cross-species genomic analysis of cuSCC development through the preneoplastic AK stage using matched human samples and a solar ultraviolet radiation-driven Hairless mouse model. We identify the major transcriptional drivers of this progression sequence, showing that the key genomic changes in cuSCC development occur in the normal skin to AK transition. Our data validate the use of this ultraviolet radiation-driven mouse cuSCC model for cross-species analysis and demons

SUBMITTER: Chitsazzadeh V 

PROVIDER: S-EPMC5013636 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature