Differences in graph theory functional connectivity in left and right temporal lobe epilepsy.

ABSTRACT:

Purpose

To investigate lateralized differences in limbic system functional connectivity between left and right temporal lobe epilepsy (TLE) using graph theory.

Methods

Interictal resting state fMRI was performed in 14 left TLE patients, 11 right TLE patients, and 12 controls. Graph theory analysis of 10 bilateral limbic regions of interest was conducted. Changes in edgewise functional connectivity, network topology, and regional topology were quantified, and then left and right TLE were compared.

Results

Limbic edgewise functional connectivity was predominantly reduced in both left and right TLE. More regional connections were reduced in right TLE, most prominently involving reduced interhemispheric connectivity between the bilateral insula and bilateral hippocampi. A

SUBMITTER: Chiang S 

PROVIDER: S-EPMC5013648 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature