Efficient escape from local optima in a highly rugged fitness landscape by evolving RNA virus populations.

ABSTRACT: Predicting viral evolution has proven to be a particularly difficult task, mainly owing to our incomplete knowledge of some of the fundamental principles that drive it. Recently, valuable information has been provided about mutation and recombination rates, the role of genetic drift and the distribution of mutational, epistatic and pleiotropic fitness effects. However, information about the topography of virus' adaptive landscapes is still scarce, and to our knowledge no data has been reported so far on how its ruggedness may condition virus' evolvability. Here, we show that populations of an RNA virus move efficiently on a rugged landscape and scape from the basin of attraction of a local optimum. We have evolved a set of Tobacco etch virus genotypes located at increasing distances from a

SUBMITTER: Cervera H 

PROVIDER: S-EPMC5013765 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature