Generalized Concentration Addition Modeling Predicts Mixture Effects of Environmental PPARγ Agonists.

ABSTRACT: The vast array of potential environmental toxicant combinations necessitates the development of efficient strategies for predicting toxic effects of mixtures. Current practices emphasize the use of concentration addition to predict joint effects of endocrine disrupting chemicals in coexposures. Generalized concentration addition (GCA) is one such method for predicting joint effects of coexposures to chemicals and has the advantage of allowing for mixture components to have differences in efficacy (ie, dose-response curve maxima). Peroxisome proliferator-activated receptor gamma (PPARγ) is a nuclear receptor that plays a central role in regulating lipid homeostasis, insulin sensitivity, and bone quality and is the target of an increasing number of environmental toxicants. Here, we tested th

SUBMITTER: Watt J 

PROVIDER: S-EPMC5013877 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature