A simple yet accurate correction for winner's curse can predict signals discovered in much larger genome scans.

ABSTRACT:

Motivation

For genetic studies, statistically significant variants explain far less trait variance than 'sub-threshold' association signals. To dimension follow-up studies, researchers need to accurately estimate 'true' effect sizes at each SNP, e.g. the true mean of odds ratios (ORs)/regression coefficients (RRs) or Z-score noncentralities. Naïve estimates of effect sizes incur winner's curse biases, which are reduced only by laborious winner's curse adjustments (WCAs). Given that Z-scores estimates can be theoretically translated on other scales, we propose a simple method to compute WCA for Z-scores, i.e. their true means/noncentralities.

Results

WCA of Z-scores shrinks these towards zero while, on P-value scale, multiple testing adjustment (MTA) shrinks P-values toward o

SUBMITTER: Bigdeli TB 

PROVIDER: S-EPMC5013908 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature