Somatosensory cortex functional connectivity abnormalities in autism show opposite trends, depending on direction and spatial scale.

ABSTRACT: Functional connectivity is abnormal in autism, but the nature of these abnormalities remains elusive. Different studies, mostly using functional magnetic resonance imaging, have found increased, decreased, or even mixed pattern functional connectivity abnormalities in autism, but no unifying framework has emerged to date. We measured functional connectivity in individuals with autism and in controls using magnetoencephalography, which allowed us to resolve both the directionality (feedforward versus feedback) and spatial scale (local or long-range) of functional connectivity. Specifically, we measured the cortical response and functional connectivity during a passive 25-Hz vibrotactile stimulation in the somatosensory cortex of 20 typically developing individuals and 15 individuals with au

SUBMITTER: Khan S 

PROVIDER: S-EPMC5013931 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature