Analysis of Intellectual Disability Copy Number Variants for Association With Schizophrenia.

ABSTRACT:

Importance

At least 11 rare copy number variants (CNVs) have been shown to be major risk factors for schizophrenia (SZ). These CNVs also increase the risk for other neurodevelopmental disorders, such as intellectual disability. It is possible that additional intellectual disability-associated CNVs increase the risk for SZ but have not yet been implicated in SZ because of previous studies being underpowered.

Objective

To examine whether additional CNVs implicated in intellectual disability represent novel SZ risk loci.

Design, setting, and participants

We used single-nucleotide polymorphism (SNP) array data to evaluate a set of 51 CNVs implicated in intellectual disability (excluding the known SZ loci) in a large data set of patients with SZ and healthy persons serving

SUBMITTER: Rees E 

PROVIDER: S-EPMC5014093 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature