Spinal cord injury-induced immune deficiency syndrome enhances infection susceptibility dependent on lesion level.

ABSTRACT: Pneumonia is the leading cause of death after acute spinal cord injury and is associated with poor neurological outcome. In contrast to the current understanding, attributing enhanced infection susceptibility solely to the patient's environment and motor dysfunction, we investigate whether a secondary functional neurogenic immune deficiency (spinal cord injury-induced immune deficiency syndrome, SCI-IDS) may account for the enhanced infection susceptibility. We applied a clinically relevant model of experimental induced pneumonia to investigate whether the systemic SCI-IDS is functional sufficient to cause pneumonia dependent on spinal cord injury lesion level and investigated whether findings are mirrored in a large prospective cohort study after human spinal cord injury. In a mouse model

SUBMITTER: Brommer B 

PROVIDER: S-EPMC5014125 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature