Misoprostol for primary versus secondary prevention of postpartum haemorrhage: a cluster-randomised non-inferiority community trial.

ABSTRACT:

Objective

To assess whether secondary prevention, which preemptively treats women with above-average postpartum bleeding, is non-inferior to universal prophylaxis.

Design

A cluster-randomised non-inferiority community trial.

Setting

Health sub-centres and home deliveries in the Bijapur district of Karnataka, India.

Population

Women with low-risk pregnancies who were eligible for delivery with an Auxiliary Nurse Midwife at home or sub-centre and who consented to be part of the study.

Methods

Auxiliary Nurse Midwifes were randomised to secondary prevention using 800 mcg sublingual misoprostol administered to women with postpartum blood loss ≥350 ml or to universal prophylaxis using 600 mcg oral misoprostol administered to all women during the third stage o

SUBMITTER: Raghavan S 

PROVIDER: S-EPMC5014137 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature