Randomization methods in emergency setting trials: a descriptive review.

ABSTRACT:

Background

Quasi-randomization might expedite recruitment into trials in emergency care settings but may also introduce selection bias.

Methods

We searched the Cochrane Library and other databases for systematic reviews of interventions in emergency medicine or urgent care settings. We assessed selection bias (baseline imbalances) in prognostic indicators between treatment groups in trials using true randomization versus trials using quasi-randomization.

Results

Seven reviews contained 16 trials that used true randomization and 11 that used quasi-randomization. Baseline group imbalance was identified in four trials using true randomization (25%) and in two quasi-randomized trials (18%). Of the four truly randomized trials with imbalance, three concealed treatment allo

SUBMITTER: Corbett MS 

PROVIDER: S-EPMC5014172 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature