Intramyocellular Lipid and Impaired Myofiber Contraction in Normal Weight and Obese Older Adults.

ABSTRACT:

Background

Evidence implicates the amount and location of fat in aging-related loss of muscle function; however, whether intramyocellular lipids affect muscle contractile capacity is unknown.

Methods

We compared both in vivo knee extensor muscle strength, power, and quality and in vitro mechanical properties of vastus lateralis single-muscle fibers between normal weight (NW) and obese older adults and determined the relationship between muscle lipid content (both intramuscular adipose tissue and intramyocellular lipids) and in vivo and in vitro muscle function in NW and obese individuals.

Results

The obese group had a greater percentage of type-I fibers compared to the NW group. The cross-sectional area of type-I fibers was greater in obese compared to NW; however, ma

SUBMITTER: Choi SJ 

PROVIDER: S-EPMC5014190 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature