TRNAmodpred: A computational method for predicting posttranscriptional modifications in tRNAs.

ABSTRACT: tRNA molecules contain numerous chemically altered nucleosides, which are formed by enzymatic modification of the primary transcripts during the complex tRNA maturation process. Some of the modifications are introduced by single reactions, while other require complex series of reactions carried out by several different enzymes. The location and distribution of various types of modifications vary greatly between different tRNA molecules, organisms and organelles. We have developed a computational method tRNAmodpred, for predicting modifications in tRNA sequences. Briefly, our method takes as an input one or more unmodified tRNA sequences and a set of protein sequences corresponding to a proteome of a cell. Subsequently it identifies homologs of known tRNA modification enzymes in the proteom

SUBMITTER: Machnicka MA 

PROVIDER: S-EPMC5014562 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature