Recent advances and future of immunotherapy for glioblastoma.

ABSTRACT:

Introduction

Outcome for glioma (GBM) remains dismal despite advances in therapeutic interventions including chemotherapy, radiotherapy and surgical resection. The overall survival benefit observed with immunotherapies in cancers such as melanoma and prostate cancer has fuelled research into evaluating immunotherapies for GBM.

Areas covered

Preclinical studies have brought a wealth of information for improving the prognosis of GBM and multiple clinical studies are evaluating a wide array of immunotherapies for GBM patients. This review highlights advances in the development of immunotherapeutic approaches. We discuss the strategies and outcomes of active and passive immunotherapies for GBM including vaccination strategies, gene therapy, check point blockade and adoptive T ce

SUBMITTER: Kamran N 

PROVIDER: S-EPMC5014608 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature