Increased incidence of FBXW7 and POLE proofreading domain mutations in young adult colorectal cancers.

ABSTRACT:

Background

The incidence and outcomes of patients with colorectal cancer (CRC) varies by age. Younger patients tend to have sporadic cancers that are not detected by screening and worse survival. To understand whether genetic differences exist between age cohorts, the authors sought to characterize unique genetic alterations in patients with CRC.

Methods

In total, 283 patients who were diagnosed with sporadic CRC between 1998 and 2010 were identified and divided by age into 2 cohorts-ages ≤45 years (the younger cohort) and ≥65 years (the older cohort)-and targeted exome sequencing was performed. The Fisher exact test was used to detect differences in mutation frequencies between the 2 groups. Whole exome sequencing was performed on 21 additional younger patient samples for v

SUBMITTER: Kothari N 

PROVIDER: S-EPMC5014625 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature