IL-4 production by group 2 innate lymphoid cells promotes food allergy by blocking regulatory T-cell function.

ABSTRACT:

Background

Food allergy is a major health issue, but its pathogenesis remains obscure. Group 2 innate lymphoid cells (ILC2s) promote allergic inflammation. However their role in food allergy is largely unknown.

Objective

We sought to investigate the role of ILC2s in food allergy.

Methods

Food allergy-prone mice with a gain-of-function mutation in the IL-4 receptor α chain (Il4raF709) were orally sensitized with food allergens, and the ILC2 compartment was analyzed. The requirement for ILC2s in food allergy was investigated by using Il4raF709, IL-33 receptor-deficient (Il1rl1(-/-)), IL-13-deficient (Il13(-/-)), and IL-4-deficient (Il4(-/-)) mice and by adoptive transfer of in vitro-expanded ILC2s. Direct effects of ILC2s on regulatory T (Treg) cells and mast cells were

SUBMITTER: Noval Rivas M 

PROVIDER: S-EPMC5014699 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature