Ontology highlight
ABSTRACT:
SUBMITTER: Yu L
PROVIDER: S-EPMC5014706 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Yu Lei L Chibnik Lori B LB Yang Jingyun J McCabe Cristin C Xu Jishu J Schneider Julie A JA De Jager Philip L PL Bennett David A DA
Alzheimer's & dementia : the journal of the Alzheimer's Association 20160324 9
<h4>Introduction</h4>We investigated the change in DNA methylation in peripheral blood CD4+ lymphocytes over time, examined the relation between CD4+ lymphocytes and brain methylation, and compared their associations with AD pathology.<h4>Methods</h4>Genome-wide methylation was measured three times in 41 older persons using Illumina Infinium HumanMethylation450 array. The two CD4+ lymphocytes measures were at study baseline and proximate to death. Brain tissue came from frozen dorsolateral prefr ...[more]