Use of transient elastography in patients with HIV-HCV coinfection: A systematic review and meta-analysis.

ABSTRACT:

Background and aim

Patients with HIV-hepatitis C virus (HCV) coinfection progress towards liver fibrosis and cirrhosis more rapidly compared with HCV mono-infected individuals. This necessitates an accurate assessment of liver stiffness with transient elastography to guide treatment.

Methods

Searches of PubMed, EMBASE, Web of Science, and the Cochrane Library databases were performed through January 2016 to assess the diagnostic accuracy of transient elastography for liver stiffness in the HIV-HCV population. Included studies were analyzed according to the Cochrane DTA Working Group methodology. Bivariate and hierarchical models were used to compute pooled sensitivity and specificity. Positive and negative likelihood ratios were also determined. A Fagan nomogram was construc

SUBMITTER: Njei B 

PROVIDER: S-EPMC5014713 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature