Identification of human RNA editing sites: A historical perspective.

ABSTRACT: A-to-I RNA editing is an essential gene regulatory mechanism. Once thought to be a rare phenomenon only occurring in a few transcripts, the emergence of high-throughput RNA sequencing has facilitated the identification of over 2 million RNA editing sites in the human transcriptome. In this review, we survey the current RNA-seq based methods as well as historical methods used to identify RNA editing sites.

SUBMITTER: Ramaswami G 

PROVIDER: S-EPMC5014717 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature