From Metabonomics to Pharmacometabonomics: The Role of Metabolic Profiling in Personalized Medicine.

ABSTRACT: Variable patient responses to drugs are a key issue for medicine and for drug discovery and development. Personalized medicine, that is the selection of medicines for subgroups of patients so as to maximize drug efficacy and minimize toxicity, is a key goal of twenty-first century healthcare. Currently, most personalized medicine paradigms rely on clinical judgment based on the patient's history, and on the analysis of the patients' genome to predict drug effects i.e., pharmacogenomics. However, variability in patient responses to drugs is dependent upon many environmental factors to which human genomics is essentially blind. A new paradigm for predicting drug responses based on individual pre-dose metabolite profiles has emerged in the past decade: pharmacometabonomics, which is defined a

SUBMITTER: Everett JR 

PROVIDER: S-EPMC5014868 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature