GADL1 variant and medication adherence in predicting response to lithium maintenance treatment in bipolar I disorder.

ABSTRACT:

Background

Genetic variants and medication adherence have been identified to be the main factors contributing to lithium treatment response in bipolar disorders.

Aims

To simultaneously examine effects of variant glutamate decarboxylase-like protein 1 (GADL1) and medication adherence on response to lithium maintenance treatment in Han Chinese patients with bipolar I (BPI) disorder.

Method

Frequencies of manic and depressive episodes between carriers and non-carriers of the effective GADL1 rs17026688 T allele during the cumulative periods of off-lithium, poor adherence to lithium treatment and good adherence to lithium treatment were compared in Han Chinese patients with BPI disorder (n=215).

Results

GADL1 rs17026688 T carriers had sig

SUBMITTER: Chen CK 

PROVIDER: S-EPMC5015003 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature