Alterations of mitochondrial dynamics allow retrograde propagation of locally initiated axonal insults.

ABSTRACT: In chronic neurodegenerative syndromes, neurons progressively die through a generalized retraction pattern triggering retrograde axonal degeneration toward the cell bodies, which molecular mechanisms remain elusive. Recent observations suggest that direct activation of pro-apoptotic signaling in axons triggers local degenerative events associated with early alteration of axonal mitochondrial dynamics. This raises the question of the role of mitochondrial dynamics on both axonal vulnerability stress and their implication in the spreading of damages toward unchallenged parts of the neuron. Here, using microfluidic chambers, we assessed the consequences of interfering with OPA1 and DRP1 proteins on axonal degeneration induced by local application of rotenone. We found that pharmacological inh

SUBMITTER: Lassus B 

PROVIDER: S-EPMC5015069 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature