Ontology highlight
ABSTRACT:
SUBMITTER: Krishnan P
PROVIDER: S-EPMC5015097 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Krishnan Preethi P Ghosh Sunita S Wang Bo B Heyns Mieke M Li Dongping D Mackey John R JR Kovalchuk Olga O Damaraju Sambasivarao S
Scientific reports 20160908
Transfer RNAs (tRNAs, key molecules in protein synthesis) have not been investigated as potential prognostic markers in breast cancer (BC), despite early findings of their dysregulation and diagnostic potential. We aim to comprehensively profile tRNAs from breast tissues and to evaluate their role as prognostic markers (Overall Survival, OS and Recurrence Free Survival, RFS). tRNAs were profiled from 11 normal breast and 104 breast tumor tissues using next generation sequencing. We adopted a Cas ...[more]