Secreted primary human malignant mesothelioma exosome signature reflects oncogenic cargo.

ABSTRACT: Malignant mesothelioma (MM) is a highly-aggressive heterogeneous malignancy, typically diagnosed at advanced stage. An important area of mesothelioma biology and progression is understanding intercellular communication and the contribution of the secretome. Exosomes are secreted extracellular vesicles shown to shuttle cellular cargo and direct intercellular communication in the tumour microenvironment, facilitate immunoregulation and metastasis. In this study, quantitative proteomics was used to investigate MM-derived exosomes from distinct human models and identify select cargo protein networks associated with angiogenesis, metastasis, and immunoregulation. Utilising bioinformatics pathway/network analyses, and correlation with previous studies on tumour exosomes, we defined a select meso

SUBMITTER: Greening DW 

PROVIDER: S-EPMC5015102 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature