Expression of pre-selected TMEMs with predicted ER localization as potential classifiers of ccRCC tumors.

ABSTRACT:

Background

VHL inactivation is the most established molecular characteristic of clear cell renal cell carcinoma (ccRCC), with only a few additional genes implicated in development of this kidney tumor. In recently published ccRCC gene expression meta-analysis study we identified a number of deregulated genes with limited information available concerning their biological role, represented by gene transcripts belonging to transmembrane proteins family (TMEMs). TMEMs are predicted to be components of cellular membranes, such as mitochondrial membranes, ER, lysosomes and Golgi apparatus. Interestingly, the function of majority of TMEMs remains unclear. Here, we analyzed expression of ten TMEM genes in the context of ccRCC progression and development, and characterized these proteins bi

SUBMITTER: Wrzesinski T 

PROVIDER: S-EPMC5015219 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature