Obesity Is Associated With Progression of Atherosclerosis During Statin Treatment.

ABSTRACT:

Background

This study aimed to determine the relationship of statin therapy and cardiovascular risk factors to changes in atherosclerosis in the carotid artery.

Methods and results

Carotid magnetic resonance imaging was used to evaluate 106 hyperlipidemic participants at baseline and after 12 months of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (statin) treatment. Multivariable logistic regression was used to determine factors associated with progression (change in carotid wall volume >0) or regression (change ≤0) of carotid atherosclerosis. Computed tomography coronary calcium scores were obtained at baseline for all participants. The median age was 65 years (interquartile range 60-69 years), and 63% of the participants were male. Body mass index >30, elevate

SUBMITTER: Sandfort V 

PROVIDER: S-EPMC5015399 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature