Prospective study evaluating the impact of tissue confirmation of metastatic disease in patients with breast cancer.

ABSTRACT:

Purpose

Decisions about treatment for women with metastatic breast cancer are usually based on the estrogen (ER), progesterone (PgR), and human epidermal growth factor receptor 2 (HER2) status of the primary tumor. Retrospective data suggest that discordance between primary and metastatic lesions leads to detrimental outcome. This prospective study investigated receptor status of primary tumors and metastases in the same patient and assessed the impact of discordance on patient management and survival.

Patients and methods

Biopsies of suspected metastases were analyzed for ER, PgR, and HER2. Primary tumors and metastases were analyzed using similar methodology. The treating oncologist indicated a treatment plan before and after biopsy to determine whether the result influenc

SUBMITTER: Amir E 

PROVIDER: S-EPMC5015424 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature