Mutation analysis of exon1 of bone morphogenetic protein-15 gene in Iranian patients with polycystic ovarian syndrome.

ABSTRACT:

Background

With the prevalence of 6-10%, polycystic ovarian syndrome (PCOS) is considered the most common endocrinological disorder affecting women in their reproductive age. It has been suggested that genetic factors participate in the development of PCOS. Follicular development has been considered as one of the impaired processes in PCOS. Bone morphogenetic protein-15 (BMP-15) gene is a candidate gene in follicular development and its variants may play role in pathogenesis of PCOS.

Objective

To investigate whether BMP-15 gene mutations are present in Iranian women with PCOS.

Materials and methods

In this cross-sectional study 5 ml venous blood samples was taken from 70 PCOS women referring to Afzalipour Hospital, Kerman University of Medical Sciences, Kerman, Iran,

SUBMITTER: Mehdizadeh A 

PROVIDER: S-EPMC5015667 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature