SDF1 Polymorphisms Influence Outcome in Patients with Symptomatic Cardiovascular Disease.

ABSTRACT:

Background

SDF1 and its cognate receptors CXCR4 and CXCR7 are involved in myocardial repair and are associated with outcome in cardiovascular patients. Hence, we aimed to investigate clinically significant SDF1 SNPs for their prognostic impact in patients with cardiovascular disease.

Methods and results

Genotyping for selected SDF1 variants (rs1065297, rs2839693, rs1801157, rs266087, rs266085 and rs266089 was performed in patients (n = 872) who underwent percutaneous coronary intervention. Carriers of variant rs2839693 and rs266089 showed significantly higher cumulative event-free survival compared with non-carriers. All other polymorphisms had no relevant influence on outcome. Multivariate Cox regression analysis showed a significant correlation of these SNPs with cardiovas

SUBMITTER: Rath D 

PROVIDER: S-EPMC5015912 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature