Microsporidia Intracellular Development Relies on Myc Interaction Network Transcription Factors in the Host.

ABSTRACT: Microsporidia are ubiquitous parasites that infect a wide range of animal hosts, and these fungal-related microbes undergo their entire replicative lifecycle inside of host cells. Despite being widespread in the environment and causing medical and agricultural harm, virtually nothing is known about the host factors important to facilitate their growth and development inside of host cells. Here, we perform a genetic screen to identify host transcription factors important for development of the microsporidian pathogen Nematocida parisii inside intestinal cells of its natural host, the nematode Caenorhabditis elegans Through this screen, we identified the C. elegans Myc family of transcription factors as key host regulators of microsporidia growth and development. The Mad-like transcription f

SUBMITTER: Botts MR 

PROVIDER: S-EPMC5015929 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature