Plethysmography Phenotype QTL in Mice Before and After Allergen Sensitization and Challenge.

ABSTRACT: Allergic asthma is common airway disease that is characterized in part by enhanced airway constriction in response to nonspecific stimuli. Genome-wide association studies have identified multiple loci associated with asthma risk in humans, but these studies have not accounted for gene-environment interactions, which are thought to be important factors in asthma. To identify quantitative trait loci (QTL) that regulate responses to a common human allergen, we applied a house dust mite mouse (HDM) model of allergic airway disease (AAD) to 146 incipient lines of the Collaborative Cross (CC) and the CC founder strains. We employed a longitudinal study design in which mice were phenotyped for response to the bronchoconstrictor methacholine both before and after HDM sensitization and challenge us

SUBMITTER: Kelada SN 

PROVIDER: S-EPMC5015943 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature