Altered Refractive Development in Mice With Reduced Levels of Retinal Dopamine.

ABSTRACT:

Purpose

The neuromodulator dopamine (DA) has been implicated in the prevention of excessive ocular elongation and myopia in various animal models. This study used retina-specific DA knockout mice to investigate the role of retinal DA in refractive development and susceptibility to experimental myopia.

Methods

Measurements of refractive error, corneal curvature, and ocular biometrics were obtained as a function of age for both untreated and form-deprived (FD) groups of retina-specific tyrosine hydroxylase knockout (rTHKO) and control (Ctrl) mice. Retinas from each group were analyzed by HPLC for levels of DA and its primary metabolite (DOPAC).

Results

Under normal visual conditions, rTHKO mice showed significantly myopic refractions (F(1,188) = 7.602, P < 0.001) and st

SUBMITTER: Bergen MA 

PROVIDER: S-EPMC5015967 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature