LNK/SH2B3 Loss of Function Promotes Atherosclerosis and Thrombosis.

ABSTRACT:

Rationale

Human genome-wide association studies have revealed novel genetic loci that are associated with coronary heart disease. One such locus resides in LNK/SH2B3, which in mice is expressed in hematopoietic cells and suppresses thrombopoietin signaling via its receptor myeloproliferative leukemia virus oncogene. However, the mechanisms underlying the association of LNK single-nucleotide polymorphisms with coronary heart disease are poorly understood.

Objective

To understand the functional effects of LNK single-nucleotide polymorphisms and explore the mechanisms whereby LNK loss of function impacts atherosclerosis and thrombosis.

Methods and results

Using human cord blood, we show that the common TT risk genotype (R262W) of LNK is associated with expansion of hemat

SUBMITTER: Wang W 

PROVIDER: S-EPMC5016083 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature