Marine ω-3 Polyunsaturated Fatty Acid Intake and Risk of Colorectal Cancer Characterized by Tumor-Infiltrating T Cells.

ABSTRACT:

Importance

Marine ω-3 polyunsaturated fatty acids (PUFAs), including eicosapentaenoic acid, docosahexaenoic acid, and docosapentaenoic acid, possess potent immunomodulatory activity and may protect against cancer development. However, evidence relating marine ω-3 PUFAs to colorectal cancer (CRC) risk remains inconclusive.

Objective

To test the hypothesis that marine ω-3 PUFA intake may be associated with lower risk of CRC subsets characterized by immune infiltrate.

Design, setting, and participants

This prospective cohort study was conducted among participants in the Nurses' Health Study (1984-2010) and Health Professionals Follow-up Study (1986-2010).

Exposures

Intake of marine ω-3 PUFAs.

Main outcomes and measures

Incidence of CRC characterized by CD3+

SUBMITTER: Song M 

PROVIDER: S-EPMC5016204 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature