Systematic Discovery of Human Gene Function and Principles of Modular Organization through Phylogenetic Profiling.

ABSTRACT: Functional links between genes can be predicted using phylogenetic profiling, by correlating the appearance and loss of homologs in subsets of species. However, effective genome-wide phylogenetic profiling has been hindered by the large fraction of human genes related to each other through historical duplication events. Here, we overcame this challenge by automatically profiling over 30,000 groups of homologous human genes (orthogroups) representing the entire protein-coding genome across 177 eukaryotic species (hOP profiles). By generating a full pairwise orthogroup phylogenetic co-occurrence matrix, we derive unbiased genome-wide predictions of functional modules (hOP modules). Our approach predicts functions for hundreds of poorly characterized genes. The results suggest evolutionary co

SUBMITTER: Dey G 

PROVIDER: S-EPMC5016211 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature