Viral metagenomics applied to blood donors and recipients at high risk for blood-borne infections.

ABSTRACT:

Background

Characterisation of human-associated viral communities is essential for epidemiological surveillance and to be able to anticipate new potential threats for blood transfusion safety. In high-resource countries, the risk of blood-borne agent transmission of well-known viruses (HBV, HCV, HIV and HTLV) is currently considered to be under control. However, other unknown or unsuspected viruses may be transmitted to recipients by blood-derived products. To investigate this, the virome of plasma from individuals at high risk for parenterally and sexually transmitted infections was analysed by high throughput sequencing (HTS).

Materials and methods

Purified nucleic acids from two pools of 50 samples from recipients of multiple transfusions, and three pools containing seven

SUBMITTER: Sauvage V 

PROVIDER: S-EPMC5016298 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature