Complete Androgen Insensitivity Syndrome in Three Generations of Indian Pedigree.

ABSTRACT:

Background

Androgen insensitivity syndrome or testicular feminization syndrome is a rare X-linked recessive disorder, which encompasses a wide range of phenotypes that are caused by numerous different mutations in the androgen receptor gene. Complete androgen insensitivity syndrome occurs when the body cannot use androgens at all. People with this form of the condition have the external sex characteristics of females, but do not have a uterus and therefore do not menstruate and are unable to conceive a child (infertile).

Methods

In this paper, we report three cases of familial complete androgen insensitivity syndrome who presented with primary amenorrhea.

Results

Physical examination, ultrasonography studies, and biochemical, karyotype, and molecular cytogenetic analy

SUBMITTER: Kar B 

PROVIDER: S-EPMC5016389 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature