Distinct Aging Effects on Functional Networks in Good and Poor Cognitive Performers.

ABSTRACT: Brain network hubs are susceptible to normal aging processes and disruptions of their functional connectivity are detrimental to decline in cognitive functions in older adults. However, it remains unclear how the functional connectivity of network hubs cope with cognitive heterogeneity in an aging population. This study utilized cognitive and resting-state functional magnetic resonance imaging data, cluster analysis, and graph network analysis to examine age-related alterations in the network hubs' functional connectivity of good and poor cognitive performers. Our results revealed that poor cognitive performers showed age-dependent disruptions in the functional connectivity of the right insula and posterior cingulate cortex (PCC), while good cognitive performers showed age-related disrupti

SUBMITTER: Lee A 

PROVIDER: S-EPMC5016512 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature