Super-Resolution Imaging of Plasma Membrane Proteins with Click Chemistry.

ABSTRACT: Besides its function as a passive cell wall, the plasma membrane (PM) serves as a platform for different physiological processes such as signal transduction and cell adhesion, determining the ability of cells to communicate with the exterior, and form tissues. Therefore, the spatial distribution of PM components, and the molecular mechanisms underlying it, have important implications in various biological fields including cell development, neurobiology, and immunology. The existence of confined compartments in the plasma membrane that vary on many length scales from protein multimers to micrometer-size domains with different protein and lipid composition is today beyond all questions. As much as the physiology of cells is controlled by the spatial organization of PM components, the study o

SUBMITTER: Mateos-Gil P 

PROVIDER: S-EPMC5016519 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature