Gene-environment interaction of genome-wide association study-identified susceptibility loci and meat-cooking mutagens in the etiology of renal cell carcinoma.

ABSTRACT:

Background

Meat-cooking mutagens may be associated with renal cell carcinoma (RCC) risk. In the current study, the authors examined associations between meat-cooking mutagens, genetic susceptibility variants, and risk of RCC.

Methods

The authors used 659 newly diagnosed RCC cases and 699 healthy controls to investigate the association between dietary intake of meat-cooking mutagens and RCC. They examined whether associations varied by risk factors for RCC and genetic susceptibility variants previously identified from genome-wide association studies. Odds ratios and 95% confidence intervals were estimated using tertiles of intake of dietary polycyclic aromatic hydrocarbons/heterocyclic amines.

Results

Dietary intake of the mutagenic compounds 2-amino-3,8-dimethylimidaz

SUBMITTER: Melkonian SC 

PROVIDER: S-EPMC5016565 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature