Expression of candidate genes associated with obesity in peripheral white blood cells of Mexican children.

ABSTRACT:

Introduction

Obesity is a chronic, complex, and multifactorial disease, characterized by excess body fat. Diverse studies of the human genome have led to the identification of susceptibility genes that contribute to obesity. However, relatively few studies have addressed specifically the association between the level of expression of these genes and obesity.

Material and methods

We studied 160 healthy and obese unrelated Mexican children aged 6 to 14 years. We measured the transcriptional expression of 20 genes associated with obesity, in addition to the biochemical parameters, in peripheral white blood cells. The detection of mRNA levels was performed using the OpenArray Real-Time PCR System (Applied Biosystems).

Results

Obese children exhibited higher values of fast

SUBMITTER: Ulloa-Martinez M 

PROVIDER: S-EPMC5016575 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature