Structural Plasticity of Cholesteryl Ester Transfer Protein Assists the Lipid Transfer Activity.

ABSTRACT: Cholesteryl ester transfer protein (CETP) mediates the transfer of cholesteryl esters (CEs) and triglycerides between different lipoproteins. Recent studies have shown that blocking the function of CETP can increase the level of HDL cholesterol in blood plasma and suppress the risk of cardiovascular disease. Hence, understanding the structure, dynamics, and mechanism by which CETP transfers the neutral lipids has received tremendous attention in last decade. Although the recent crystal structure has provided direct evidence of the existence of strongly bound CEs in the CETP core, very little is known about the mechanism of CE/triglyceride transfer by CETP. In this study, we explore the large scale dynamics of CETP by means of multimicrosecond molecular dynamics simulations and normal mode

SUBMITTER: Chirasani VR 

PROVIDER: S-EPMC5016684 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature