Are fiducial markers useful surrogates when using respiratory gating to reduce motion of gastroesophageal junction tumors?

ABSTRACT:

Background

Radiation therapy (RT) is an integral component of the management of gastroesophageal junction (GEJ) tumors. We evaluated the use of implanted radiopaque fiducials as tumor surrogates to allow for more focal delivery of RT to these mobile tumors when using respiratory gating (RG) to reduce motion.

Material and methods

We analyzed four-dimensional computed tomography scans of 20 GEJ patients treated with RG and assessed correlation between tumor and implanted fiducial motion over the whole respiratory cycle and within a clinically realistic gate around end-exhalation. We evaluated fiducial motion concordance in 11 patients with multiple fiducials.

Results

Gating reduced anterior-posterior (AP) and superior-inferior (SI) mean tumor and fiducial motions by ove

SUBMITTER: Liu F 

PROVIDER: S-EPMC5016835 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature