Lipid profile status and other related factors in patients with Hyperphenylalaninaemia.

ABSTRACT:

Background

The mainstay of treating patients with phenylketonuria (PKU) is based on a Phe-restricted diet, restrictive in natural protein combined with Phe-free L-amino acid supplements and low protein foods. This PKU diet seems to reduce atherogenesis and confer protection against cardiovascular diseases but the results from the few published studies have been inconclusive. The aim of our study was to evaluate the relationship between the lipid profile and several treatment-related risk factors in patients with hyperphenylalaninaemia (HPA) in order to optimize their monitoring.

Methods

We conducted a cross-sectional multicentre study. A total of 141 patients with HPA were classified according to age, phenotype, type of treatment and dietary adherence. Annual median blood ph

SUBMITTER: Couce ML 

PROVIDER: S-EPMC5016957 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature