Essential functions linked with structural disorder in organisms of minimal genome.

ABSTRACT:

Unlabelled

Intrinsically disordered regions (IDRs) of proteins fulfill important regulatory roles in most organisms. However, the proteins of certain endosymbiont and intracellular pathogenic bacteria with extremely reduced genomes contain disproportionately small amounts of IDRs, consisting almost entirely of folded domains. As their genomes co-evolving with their hosts have been reduced in unrelated lineages, the proteomes of these bacteria represent independently evolved minimal protein sets. We systematically analyzed structural disorder in a representative set of such minimal organisms to see which types of functionally relevant longer IDRs are invariably retained in them. We found that a few characteristic functions are consistently linked with conformational disorder: riboso

SUBMITTER: Pancsa R 

PROVIDER: S-EPMC5016991 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature