Coassociations between IL10 polymorphisms, IL-10 production, helminth infection, and asthma/wheeze in an urban tropical population in Brazil.

ABSTRACT:

Background

Helminth infections are associated with protection against allergies. It is postulated that IL-10 production after helminth infection suppresses skin hypersensitivity and increases IgG₄ production, protecting against allergies.

Objective

We aimed to determine whether IL10 polymorphisms are associated with helminth infection and the risk of wheeze and allergy.

Methods

Twelve IL10 single nucleotide polymorphisms were genotyped in 1353 children aged 4 to 11 years living in a poor urban area in Salvador, Brazil. Wheezing status, Ascaris lumbricoides and Trichuris trichiura infection, IL-10 production by peripheral blood leukocytes stimulated with A lumbricoides extract, serum total IgE levels, specific IgE levels, skin prick test responses to common aeroallerge

SUBMITTER: Figueiredo CA 

PROVIDER: S-EPMC5017514 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature