Implication of Terminal Residues at Protein-Protein and Protein-DNA Interfaces.

ABSTRACT: Terminal residues of protein chains are charged and more flexible than other residues since they are constrained only on one side. Do they play a particular role in protein-protein and protein-DNA interfaces? To answer this question, we considered large sets of non-redundant protein-protein and protein-DNA complexes and analyzed the status of terminal residues and their involvement in interfaces. In protein-protein complexes, we found that more than half of terminal residues (62%) are either modified by attachment of a tag peptide (10%) or have missing coordinates in the analyzed structures (52%). Terminal residues are almost exclusively located at the surface of proteins (94%). Contrary to charged residues, they are not over or under-represented in protein-protein interfaces, but strongly

SUBMITTER: Martin OM 

PROVIDER: S-EPMC5017611 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature